The Formulation Science — Why SÉRÈNE Uses Dimethylsilanol Hyaluronate | SÉRÈNE Suisse
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Formulation Science

The Hydration
Science

Why standard hyaluronic acid sits on the surface — and why SÉRÈNE uses Dimethylsilanol Hyaluronate for deep, lasting hydration.

5-minute read·Active Ingredient Science· SÉRÈNE Suisse

Hyaluronic acid is the most marketed ingredient in luxury skincare. It is also, in its most common form, one of the least effective at addressing the underlying hydration deficit that makes skin look aged and fatigued. Standard high-molecular-weight sodium hyaluronate — the form in the majority of luxury serums — cannot penetrate the stratum corneum. It sits on the skin's surface, creating a film that temporarily reduces the appearance of dehydration. The SÉRÈNE Elixir uses Dimethylsilanol Hyaluronate, a silicon bound hyaluronate for deep and lasting hydration.

The penetration problem with
standard hyaluronic acid

Standard hyaluronic acid (HA) as sodium hyaluronate has a molecular weight typically ranging from 1,000,000 to 2,000,000 Daltons in most skincare applications. The skin's stratum corneum acts as a selective barrier, generally permeable only to molecules below approximately 500 Daltons. Standard HA is therefore physically incapable of penetrating to the viable dermis — the tissue where fibroblasts maintain the skin's water-holding extracellular matrix and where structural dehydration actually occurs.

What standard HA does provide is real and measurable: surface film-forming hydration, immediate reduction in the appearance of fine lines through surface plumping, and a pleasant application texture. These are not trivial benefits. But they do not address the underlying structural cause of the dehydrated appearance — the progressive depletion of the dermis's water-holding capacity.

Why SÉRÈNE uses
Dimethylsilanol Hyaluronate

Dimethylsilanol Hyaluronate combines the water-binding hyaluronic acid molecule with dimethylsilanol chemistry — a silicon bound hyaluronate, among the first ingredients in the Elixir formula, for deep and lasting hydration and a visibly plumper look.

What Trans-Epidermal Water Loss
actually looks like on your skin

Trans-Epidermal Water Loss (TEWL) — the continuous evaporation of water through the skin barrier into the environment — is the primary mechanism of facial dehydration. In dry or air-conditioned environments, TEWL can exceed the skin's natural barrier repair rate, creating a cumulative hydration deficit that manifests as dullness, accentuated fine lines, loss of the morning plumpness that used to return after a full night's sleep, and a general "tired" appearance that persists regardless of sleep quality or water intake.

Standard moisturisers address TEWL by providing occlusivity — forming a surface barrier that slows evaporation. This is effective as a treatment but it does not restore the depleted dermal water reserves that TEWL has been draining over weeks and months.

Dimethylsilanol Hyaluronate is one of the core hydration actives in the SÉRÈNE Elixir Gold & Caviar Serum. Applied morning and evening to toned skin, it delivers deep, lasting hydration with every application.

Shop the Elixir Serum

Deep, lasting
hydration.

The SÉRÈNE Elixir Gold & Caviar Serum. Dimethylsilanol Hyaluronate alongside Syn®-Coll, Organic Edelweiss, and Marine Caviar.

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